try: import uctypes except ImportError: print("SKIP") raise SystemExit desc = { "arr": (uctypes.ARRAY | 0, uctypes.UINT8 | 2), "arr2": (uctypes.ARRAY | 2, uctypes.INT8 | 2), } data = bytearray(b"01234567") S = uctypes.struct(uctypes.addressof(data), desc, uctypes.LITTLE_ENDIAN) # Arrays of UINT8 are accessed as bytearrays print(S.arr) # But not INT8, because value range is different print(type(S.arr2)) # convert to buffer print(bytearray(S))