diff --git a/ports/webassembly/variants/pyscript/manifest.py b/ports/webassembly/variants/pyscript/manifest.py
new file mode 100644
index 0000000000..0646e1d897
--- /dev/null
+++ b/ports/webassembly/variants/pyscript/manifest.py
@@ -0,0 +1,27 @@
+require("abc")
+require("base64")
+require("collections")
+require("collections-defaultdict")
+require("copy")
+require("datetime")
+require("fnmatch")
+require("functools")
+require("gzip")
+require("hmac")
+require("html")
+require("inspect")
+require("io")
+require("itertools")
+require("locale")
+require("logging")
+require("operator")
+require("os")
+require("os-path")
+require("pathlib")
+require("stat")
+require("tarfile")
+require("tarfile-write")
+require("time")
+require("unittest")
+require("uu")
+require("zlib")
diff --git a/ports/webassembly/variants/pyscript/mpconfigvariant.h b/ports/webassembly/variants/pyscript/mpconfigvariant.h
new file mode 100644
index 0000000000..ed8e812803
--- /dev/null
+++ b/ports/webassembly/variants/pyscript/mpconfigvariant.h
@@ -0,0 +1,3 @@
+#define MICROPY_CONFIG_ROM_LEVEL                (MICROPY_CONFIG_ROM_LEVEL_FULL_FEATURES)
+#define MICROPY_GC_SPLIT_HEAP                   (1)
+#define MICROPY_GC_SPLIT_HEAP_AUTO              (1)
diff --git a/ports/webassembly/variants/pyscript/mpconfigvariant.mk b/ports/webassembly/variants/pyscript/mpconfigvariant.mk
new file mode 100644
index 0000000000..016b96a99a
--- /dev/null
+++ b/ports/webassembly/variants/pyscript/mpconfigvariant.mk
@@ -0,0 +1,3 @@
+JSFLAGS += -s ALLOW_MEMORY_GROWTH
+
+FROZEN_MANIFEST ?= variants/pyscript/manifest.py