diff --git a/datasette/app.py b/datasette/app.py
index 1d943233..2f0bf47a 100644
--- a/datasette/app.py
+++ b/datasette/app.py
@@ -149,6 +149,8 @@ class ConnectedDatabase:
 
     @property
     def size(self):
+        if self.is_memory:
+            return 0
         if self.cached_size is not None:
             return self.cached_size
         else:
diff --git a/tests/test_html.py b/tests/test_html.py
index 71dfe722..b25263cb 100644
--- a/tests/test_html.py
+++ b/tests/test_html.py
@@ -19,6 +19,11 @@ def test_homepage(app_client):
     assert "fixtures" in response.text
 
 
+def test_memory_database_page(app_client_with_memory):
+    response = app_client_with_memory.get("/:memory:")
+    assert response.status == 200
+
+
 def test_database_page_redirects_with_url_hash(app_client_with_hash):
     response = app_client_with_hash.get("/fixtures", allow_redirects=False)
     assert response.status == 302