diff --git a/.gitignore b/.gitignore
index 066009f0..277ff653 100644
--- a/.gitignore
+++ b/.gitignore
@@ -118,3 +118,9 @@ ENV/
 .DS_Store
 node_modules
 .*.swp
+
+# In case someone compiled tests/ext.c for test_load_extensions, don't
+# include it in source control.
+tests/*.dylib
+tests/*.so
+tests/*.dll
\ No newline at end of file
diff --git a/datasette/app.py b/datasette/app.py
index 1a9afc10..bb9232c9 100644
--- a/datasette/app.py
+++ b/datasette/app.py
@@ -559,7 +559,13 @@ class Datasette:
         if self.sqlite_extensions:
             conn.enable_load_extension(True)
             for extension in self.sqlite_extensions:
-                conn.execute("SELECT load_extension(?)", [extension])
+                # "extension" is either a string path to the extension 
+                # or a 2-item tuple that specifies which entrypoint to load. 
+                if isinstance(extension, tuple):
+                    path, entrypoint = extension
+                    conn.execute("SELECT load_extension(?, ?)", [path, entrypoint])
+                else:
+                    conn.execute("SELECT load_extension(?)", [extension])
         if self.setting("cache_size_kb"):
             conn.execute(f"PRAGMA cache_size=-{self.setting('cache_size_kb')}")
         # pylint: disable=no-member
diff --git a/datasette/cli.py b/datasette/cli.py
index f2a03d53..6eb42712 100644
--- a/datasette/cli.py
+++ b/datasette/cli.py
@@ -21,6 +21,7 @@ from .app import (
     pm,
 )
 from .utils import (
+    LoadExtension,
     StartupError,
     check_connection,
     find_spatialite,
@@ -128,9 +129,10 @@ def sqlite_extensions(fn):
     return click.option(
         "sqlite_extensions",
         "--load-extension",
+        type=LoadExtension(),
         envvar="SQLITE_EXTENSIONS",
         multiple=True,
-        help="Path to a SQLite extension to load",
+        help="Path to a SQLite extension to load, and optional entrypoint",
     )(fn)
 
 
diff --git a/datasette/utils/__init__.py b/datasette/utils/__init__.py
index d148cc2c..0fc87d51 100644
--- a/datasette/utils/__init__.py
+++ b/datasette/utils/__init__.py
@@ -833,6 +833,17 @@ class StaticMount(click.ParamType):
             self.fail(f"{value} is not a valid directory path", param, ctx)
         return path, dirpath
 
+# The --load-extension parameter can optionally include a specific entrypoint.
+# This is done by appending ":entrypoint_name" after supplying the path to the extension
+class LoadExtension(click.ParamType):
+    name = "path:entrypoint?"
+
+    def convert(self, value, param, ctx):
+        if ":" not in value:
+            return value
+        path, entrypoint = value.split(":", 1)
+        return path, entrypoint
+
 
 def format_bytes(bytes):
     current = float(bytes)
diff --git a/tests/ext.c b/tests/ext.c
new file mode 100644
index 00000000..5fe970d9
--- /dev/null
+++ b/tests/ext.c
@@ -0,0 +1,48 @@
+/*
+** This file implements a SQLite extension with multiple entrypoints.
+**
+** The default entrypoint, sqlite3_ext_init, has a single function "a".
+** The 1st alternate entrypoint, sqlite3_ext_b_init, has a single function "b".
+** The 2nd alternate entrypoint, sqlite3_ext_c_init, has a single function "c".
+**
+** Compiling instructions: 
+**     https://www.sqlite.org/loadext.html#compiling_a_loadable_extension
+**
+*/
+
+#include "sqlite3ext.h"
+
+SQLITE_EXTENSION_INIT1
+
+// SQL function that returns back the value supplied during sqlite3_create_function()
+static void func(sqlite3_context *context, int argc, sqlite3_value **argv) {
+  sqlite3_result_text(context, (char *) sqlite3_user_data(context), -1, SQLITE_STATIC);
+}
+
+
+// The default entrypoint, since it matches the "ext.dylib"/"ext.so" name
+#ifdef _WIN32
+__declspec(dllexport)
+#endif
+int sqlite3_ext_init(sqlite3 *db, char **pzErrMsg, const sqlite3_api_routines *pApi) {
+  SQLITE_EXTENSION_INIT2(pApi);
+  return sqlite3_create_function(db, "a", 0, 0, "a", func, 0, 0);
+}
+
+// Alternate entrypoint #1
+#ifdef _WIN32
+__declspec(dllexport)
+#endif
+int sqlite3_ext_b_init(sqlite3 *db, char **pzErrMsg, const sqlite3_api_routines *pApi) {
+  SQLITE_EXTENSION_INIT2(pApi);
+  return sqlite3_create_function(db, "b", 0, 0, "b", func, 0, 0);
+}
+
+// Alternate entrypoint #2
+#ifdef _WIN32
+__declspec(dllexport)
+#endif
+int sqlite3_ext_c_init(sqlite3 *db, char **pzErrMsg, const sqlite3_api_routines *pApi) {
+  SQLITE_EXTENSION_INIT2(pApi);
+  return sqlite3_create_function(db, "c", 0, 0, "c", func, 0, 0);
+}
diff --git a/tests/test_load_extensions.py b/tests/test_load_extensions.py
new file mode 100644
index 00000000..360bc8f3
--- /dev/null
+++ b/tests/test_load_extensions.py
@@ -0,0 +1,65 @@
+from datasette.app import Datasette
+import pytest
+from pathlib import Path
+
+# not necessarily a full path - the full compiled path looks like "ext.dylib"
+# or another suffix, but sqlite will, under the hood, decide which file
+# extension to use based on the operating system (apple=dylib, windows=dll etc)
+# this resolves to "./ext", which is enough for SQLite to calculate the rest
+COMPILED_EXTENSION_PATH = str(Path(__file__).parent / "ext")
+
+# See if ext.c has been compiled, based off the different possible suffixes.
+def has_compiled_ext():
+    for ext in ["dylib", "so", "dll"]:
+        path = Path(__file__).parent / f"ext.{ext}"
+        if path.is_file():
+            return True
+    return False
+
+
+@pytest.mark.asyncio
+@pytest.mark.skipif(not has_compiled_ext(), reason="Requires compiled ext.c")
+async def test_load_extension_default_entrypoint():
+
+    # The default entrypoint only loads a() and NOT b() or c(), so those
+    # should fail.
+    ds = Datasette(sqlite_extensions=[COMPILED_EXTENSION_PATH])
+
+    response = await ds.client.get("/_memory.json?sql=select+a()")
+    assert response.status_code == 200
+    assert response.json()["rows"][0][0] == "a"
+
+    response = await ds.client.get("/_memory.json?sql=select+b()")
+    assert response.status_code == 400
+    assert response.json()["error"] == "no such function: b"
+
+    response = await ds.client.get("/_memory.json?sql=select+c()")
+    assert response.status_code == 400
+    assert response.json()["error"] == "no such function: c"
+
+
+@pytest.mark.asyncio
+@pytest.mark.skipif(not has_compiled_ext(), reason="Requires compiled ext.c")
+async def test_load_extension_multiple_entrypoints():
+
+    # Load in the default entrypoint and the other 2 custom entrypoints, now
+    # all a(), b(), and c() should run successfully.
+    ds = Datasette(
+        sqlite_extensions=[
+            COMPILED_EXTENSION_PATH,
+            (COMPILED_EXTENSION_PATH, "sqlite3_ext_b_init"),
+            (COMPILED_EXTENSION_PATH, "sqlite3_ext_c_init"),
+        ]
+    )
+
+    response = await ds.client.get("/_memory.json?sql=select+a()")
+    assert response.status_code == 200
+    assert response.json()["rows"][0][0] == "a"
+
+    response = await ds.client.get("/_memory.json?sql=select+b()")
+    assert response.status_code == 200
+    assert response.json()["rows"][0][0] == "b"
+
+    response = await ds.client.get("/_memory.json?sql=select+c()")
+    assert response.status_code == 200
+    assert response.json()["rows"][0][0] == "c"