diff --git a/datasette/filters.py b/datasette/filters.py
index 5fd722f3..abaafc5b 100644
--- a/datasette/filters.py
+++ b/datasette/filters.py
@@ -1,5 +1,10 @@
+import json
 import numbers
-from .utils import detect_json1
+
+from .utils import (
+    detect_json1,
+    escape_sqlite,
+)
 
 
 class Filter:
@@ -52,6 +57,29 @@ class TemplatedFilter(Filter):
             return template.format(c=column, v=value)
 
 
+class InFilter(Filter):
+    key = 'in'
+    display = 'in'
+
+    def __init__(self):
+        pass
+
+    def split_value(self, value):
+        if value.startswith("["):
+            return json.loads(value)
+        else:
+            return [v.strip() for v in value.split(",")]
+
+    def where_clause(self, table, column, value, param_counter):
+        values = self.split_value(value)
+        params = [":p{}".format(param_counter + i) for i in range(len(values))]
+        sql = "{} in ({})".format(escape_sqlite(column), ", ".join(params))
+        return sql, values
+
+    def human_clause(self, column, value):
+        return "{} in {}".format(column, json.dumps(self.split_value(value)))
+
+
 class Filters:
     _filters = [
         # key, display, sql_template, human_template, format=, numeric=, no_argument=
@@ -64,8 +92,9 @@ class Filters:
         TemplatedFilter('gte', '\u2265', '"{c}" >= :{p}', '{c} \u2265 {v}', numeric=True),
         TemplatedFilter('lt', '<', '"{c}" < :{p}', '{c} < {v}', numeric=True),
         TemplatedFilter('lte', '\u2264', '"{c}" <= :{p}', '{c} \u2264 {v}', numeric=True),
-        TemplatedFilter('glob', 'glob', '"{c}" glob :{p}', '{c} glob "{v}"'),
         TemplatedFilter('like', 'like', '"{c}" like :{p}', '{c} like "{v}"'),
+        TemplatedFilter('glob', 'glob', '"{c}" glob :{p}', '{c} glob "{v}"'),
+        InFilter(),
     ] + ([TemplatedFilter('arraycontains', 'array contains', """rowid in (
             select {t}.rowid from {t}, json_each({t}.{c}) j
             where j.value = :{p}
diff --git a/docs/json_api.rst b/docs/json_api.rst
index 1ea35672..67700224 100644
--- a/docs/json_api.rst
+++ b/docs/json_api.rst
@@ -219,6 +219,15 @@ You can filter the data returned by the table based on column values using a que
 ``?column__glob=value``
     Similar to LIKE but uses Unix wildcard syntax and is case sensitive.
 
+``?column__in=value1,value2,value3``
+    Rows where column matches any of the provided values.
+
+    You can use a comma separated string, or you can use a JSON array.
+
+    The JSON array option is useful if one of your matching values itself contains a comma:
+
+    ``?column__in=["value","value,with,commas"]``
+
 ``?column__arraycontains=value``
     Works against columns that contain JSON arrays - matches if any of the values in that array match.
 
diff --git a/tests/test_filters.py b/tests/test_filters.py
index b0cb3f34..a5d6e3d0 100644
--- a/tests/test_filters.py
+++ b/tests/test_filters.py
@@ -53,6 +53,28 @@ import pytest
         ['"bar" > :p0', '"baz" is null', '"foo" is null'],
         [10]
     ),
+    (
+        {
+            'foo__in': '1,2,3',
+        },
+        ['foo in (:p0, :p1, :p2)'],
+        ["1", "2", "3"]
+    ),
+    # JSON array variants of __in (useful for unexpected characters)
+    (
+        {
+            'foo__in': '[1,2,3]',
+        },
+        ['foo in (:p0, :p1, :p2)'],
+        [1, 2, 3]
+    ),
+    (
+        {
+            'foo__in': '["dog,cat", "cat[dog]"]',
+        },
+        ['foo in (:p0, :p1)'],
+        ["dog,cat", "cat[dog]"]
+    ),
 ])
 def test_build_where(args, expected_where, expected_params):
     f = Filters(sorted(args.items()))